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pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May possibly produce loss of virologic response and achievable resistance.pentobarbital will lessen the extent or outcome of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3